Chemogenomic


Chemo genomics, or chemical genomics, is the systematic High-throughput screening (HTS) of targeted chemical libraries of small molecules against individual biological target families (e.g., nuclear receptors, kinases, proteases, etc.) with the ultimate goal of discovering novel drugs and drug targets. Typically, a few members of a target library have been well characterized where both the function has been determined and compounds that modulate the function of those targets (ligands in the case of receptor or inhibitor of enzymes) have been identified. Other members of the target family may have unknown function with no known ligands and hence are classified as adaptor orphan. Chemo genomics draw together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics  proteomics.



 


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