Medicinal Chemistry and Drug Design

Spectroscopy

In drug discovery investigations, many spectroscopic methods are used. Several mass spectrometric techniques, including Accelerator Mass Spectrometry, are being used in early drug discovery, preclinical and clinical research, as well as Phase 0 trials. Life scientists are increasingly relying on technologies such as HPLC, HPTLC, and LC-MS to study minute entities as well as larger molecules. Mass Spectrometry with liquid chromatography (LC-MS). High performance liquid chromatography (HPLC)-MS is a systematic approach that combines high resolution chromatographic separation with sensitive and selective mass spectrometric detection. It is, without a doubt, the most effective method for pharmaceutical analysis. In pharmaceutical analysis, LC-MS has been used for drug metabolism research, as well as the study and detection of contaminants and degradation products in pharmaceuticals.