B Moon Kim
Seoul National University, Republic of Korea
Title: Development of potent autoinducer-2 quorum-sensing inhibitors equipped with novel bicyclic brominated furanones against bacterial biofilm formation
Biography
Biography: B Moon Kim
Abstract
Biofilm formation is one of the critical factors affecting bacterial survival in association with bacterial virulence factors. It is effectively regulated through a process called quorum sensing, which is an intra- and interspecies bacterial communication system. According to changes in cell deinsity and species complexity, complex biological responses are triggered through the quorum sensing. Chronic inflammation of the periodontium is one of the most common inflammatory diseases, which is in part caused by subgingival biofilm formation from periodontopathogens. Particularly, the early and late colonizers in periodontal biofilms are linked together by Fusobacterium nucleatum, which is thus regarded as a major co-aggregation bridge organism in forming aqnd growing subgingival biofilms. We have previously shown that autoinducer-2 (AI-2) of F. Nucleatum, the intergeneric quorum-sensing signal molecule, can be a possible target for the inhibition of periodontal biofilm formation, since it plays a key role in intra- and interspecies interactions of periodontopathogens. Recently, inhibition of biofilm formation via AI-2 by novel brominated furanones originated from marine natural products such as those from macroalga Delisea pulchra has been reported, and further studies toward the goal of increasing the inhibition effect have been conducted. Herein, we describe the synthesis and quorum sensing inhibitory activities of new bromofuranone analogs in relation with biofilm formation by periodontopathogens such as F. nucleatum, Porphyromonas gingivalis, and Tannerella forsythia.